In the eighteenth century, Avignon remained papal but depended heavily on its relations with France. The epidemic of 1721 and economic difficulties weakened this balance.
The epidemic of 1721
Plague reached Avignon in 1721 despite protective measures introduced after its appearance in Marseille. It caused thousands of deaths. Restrictions on movement and the loss of many workers had a lasting effect on the town’s economy.
Plague in Marseille, detail of a painting by Michel Serre, Musée des Beaux-Arts
The weaknesses of the urban economy
Manufacturing and trade had to contend with French regulations. The silk industry faced serious difficulties, but Avignon’s economy cannot be reduced to smuggling alone. Commercial relations with towns in the French kingdom remained essential.
Panorama of Avignon by P. Bonnard, Musée Calvet
The French occupation of 1768–1774
From 1768 to 1774, France again occupied Avignon and the Comtat amid tensions with the Holy See. Papal sovereignty was then restored. Before the Revolution, opinions on the territories’ future remained varied; they cannot be divided simply into pro-French townspeople and pro-papal nobles.

